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Pathologic changes in chickens caused by intravenous inoculation with fowlpox virus
E Tanizaki1, T Kotani, Y Odagiri
1Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
Avian Diseases
|April 1, 1989
Summary
Fowlpox (FP) virus infects chicken kidneys, skin, and respiratory tract, causing characteristic lesions and Bollinger bodies. Viral antigens and particles were confirmed in these tissues.
Area of Science:
- Veterinary Pathology
- Virology
- Avian Diseases
Background:
- Fowlpox (FP) is a significant viral disease affecting poultry worldwide.
- Understanding the pathogenesis and tissue tropism of FP virus is crucial for disease management.
Purpose of the Study:
- To chronologically investigate the clinical and pathological manifestations of fowlpox virus infection in chickens.
- To identify the specific tissues and cellular targets of FP virus replication.
Main Methods:
- Intravenous inoculation of twenty chickens with fowlpox virus.
- Chronological clinical and gross pathological examinations.
- Microscopic, immunofluorescent, and electron microscopic examinations of affected tissues.
Main Results:
- Miliary nodules in kidneys (10-18 days postinoculation), skin papules, and upper respiratory tract lesions were observed.
- Characteristic fowlpox lesions with Bollinger bodies identified in renal tubules (4-14 days PI), thymic medulla (4-10 days PI), skin, and mucous membranes.
- Viral antigen and virus particles confirmed in lesions via immunofluorescence and electron microscopy.
Conclusions:
- The study demonstrates the systemic spread and tissue tropism of fowlpox virus in experimentally infected chickens.
- Kidneys, thymus, skin, and respiratory tract are key target organs for fowlpox virus replication.
- Microscopic and ultrastructural findings confirm the characteristic cytopathic effects and presence of viral components in fowlpox lesions.