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Relationship Between [18F]FDOPA PET Uptake, Apparent Diffusion Coefficient (ADC), and Proliferation Rate in Recurrent
Elena Karavaeva1, Robert J Harris, Kevin Leu
1Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 615, Los Angeles, CA, 90024, USA.
Molecular Imaging and Biology
|December 4, 2014
Summary
High 6-[(18)F]fluoro-L-dopa (FDOPA) uptake on PET scans correlated with low apparent diffusion coefficient (ADC) on diffusion MRI in recurrent malignant gliomas. Both imaging modalities showed associations with tumor mitotic activity.
Area of Science:
- Neuro-oncology
- Radiology
- Molecular Imaging
Background:
- Diffusion MRI and 6-[(18)F]fluoro-L-dopa (FDOPA) PET are utilized to assess malignant tumor microenvironments.
- The relationship between FDOPA uptake, apparent diffusion coefficient (ADC), and mitotic activity in recurrent malignant gliomas, particularly considering therapy effects, is not well-defined.
Purpose of the Study:
- To investigate the correlation between FDOPA uptake, diffusion MRI-derived ADC, and mitotic activity in recurrent malignant gliomas.
Main Methods:
- Retrospective analysis of 29 patients with recurrent malignant gliomas who underwent MRI and FDOPA PET before surgery.
- Quantitative voxel-wise and median measurement correlations were performed between FDOPA PET, ADC, and mitotic index.
Main Results:
- Areas of high FDOPA uptake corresponded to low ADC, and areas of high T2/FLAIR hyperintensity with low FDOPA uptake showed high ADC.
- A significant inverse correlation was observed between FDOPA uptake and ADC across all patients.
- Median FDOPA uptake positively correlated with mitotic index, while median ADC inversely correlated with mitotic index.
Conclusions:
- A significant association exists between FDOPA uptake, diffusion MRI, and mitotic activity in recurrent malignant gliomas.
- These imaging techniques may offer insights into tumor biology and aggressiveness.
