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Related Concept Videos

Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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Fibril-associated Collagen01:11

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Embryonic Connective Tissues01:20

Embryonic Connective Tissues

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During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
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Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

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Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
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Connective Tissue Fibers and Ground Substance01:17

Connective Tissue Fibers and Ground Substance

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One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...
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Updated: Apr 20, 2026

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
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Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

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Collagen type IV at the fetal-maternal interface.

C M Oefner1, A Sharkey1, L Gardner1

  • 1Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom.

Placenta
|December 4, 2014
PubMed
Summary
This summary is machine-generated.

Collagen type IV (col-IV) is newly identified in the placenta, influencing trophoblast cell invasion and tissue structure. Its expression patterns in the decidua basalis and parietalis are distinct, impacting implantation site development.

Keywords:
Alpha(IV) NC1 domainsExtracellular matrixPlacental bedReproductive cycleTrophoblast

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Area of Science:

  • Reproductive biology
  • Extracellular matrix research
  • Cellular and molecular biology

Background:

  • Extracellular matrix proteins are vital for trophoblast cell invasion.
  • The specific role of collagen type IV (col-IV) at the implantation site remains unclear.

Purpose of the Study:

  • To investigate the distribution and function of collagen types I, III, IV, and VI in the human endometrium and decidua.
  • To elucidate the role of collagen type IV in trophoblast cell invasion and placental development.

Main Methods:

  • Immunohistochemistry to map collagen distribution in the endometrium and decidua.
  • Quantitative PCR (qPCR) and immunohistochemistry to analyze col-IV alpha chain expression.
  • Transmission electron microscopy to examine placental col-IV structure.
  • Localization of col-IV alpha chain NC1 domains and collagen receptors.

Main Results:

  • Col-IV alpha chains showed increased expression during the menstrual cycle and decidualization.
  • Trophoblast cells express collagen receptors and secrete col-IV, leading to higher levels in decidua basalis versus decidua parietalis.
  • A novel 3D network of col-IV was observed in placental villi mesenchyme.

Conclusions:

  • Collagen type IV exhibits novel forms within the placenta.
  • Col-IV contributes to tissue integrity and modulates trophoblast cell invasion at the implantation site.