Related Experiment Video
Updated: Apr 20, 2026
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Prediction of long-term outcome after acute myocardial infarction using circulating miR-145
Yu-Mei Dong1, Xiao-Xia Liu, Guo-Qian Wei
1Department of Cardiology, Center for Atrial Fibrillation, Beijing Anzhen Hospital, Capital Medical University , Beijing.
Background:
Recent reports have shown that miR-145 concentration correlates with infarct size. In this paper, we attempt to predict heart failure and cardiovascular death after acute myocardial infarction using circulating miR-145 concentration.
Methods:
We assessed 246 patients with first ST-segment-elevation myocardial infarction who underwent successful percutaneous coronary intervention. We measured circulating miR-145, N-terminal fragment of the precursor B-type natriuretic peptide, myocardial-band creatine kinase, and cardiac troponin-I concentrations on day 5 after primary percutaneous coronary intervention and assessed their correlations with long-term clinical outcome.
Results:
During the one-year follow-up period, 72 patients experienced primary composite cardiac events (cardiac death or hospitalization for worsening heart failure). Multivariable Cox proportional hazards analysis indicated that circulating miR-145 (hazard ratio 7.174, 95% confidence interval 4.208-12.229); p < 0.0001) was a significant independent predictor of cardiac events after adjustment for multiple confounders.
Conclusion:
Circulating miR-145 may be a novel biomarker for predicting long-term outcome after acute myocardial infarction.
