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Force and affinity in ligand discrimination by the TCR

David Depoil1, Michael L Dustin1

  • 1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics and Musculosceletal Sciences, The University of Oxford, Roosevelt Drive, Headington, OX3 7FY, United Kingdom; Helene and Martin Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10012, USA.

Trends in Immunology
|December 4, 2014
PubMed
Summary

T cell receptor (TCR) interactions with pMHC involve force, forming a catch bond. This force-dependent mechanism is crucial for T cell activation and may be key in early immune response decisions.

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