Microemulsions based transdermal drug delivery systems.
Harini C Vadlamudi, Hyndavi Narendran, Tejeswari Nagaswaram
1Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Tirupati- 517102, India. vadlamudi.harini@gmail.com.
Current Drug Discovery Technologies
|December 4, 2014
Summary
Microemulsions offer enhanced drug delivery through the skin. Combining them with viscous gel bases improves topical applications, overcoming low viscosity issues for better drug absorption and reduced toxicity.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Microemulsions, thermodynamically stable isotropic systems of water, oil, and amphiphile, have advanced research and industry.
- Their properties include optical clarity, ease of preparation, and enhanced diffusion/absorption rates, showing potential for transdermal and dermal drug delivery.
- Low viscosity of microemulsions limits pharmaceutical applications.
Purpose of the Study:
- To review microemulsion systems and their applications in drug delivery.
- To explore microemulsion-based hydrogels and organogels as enhanced topical drug delivery systems.
- To investigate the physicochemical, mechanical, rheological, and stability aspects of these novel systems.
Main Methods:
- Review of literature on microemulsion development and applications.
- Focus on microemulsion-based hydrogels and organogels.
- Analysis of physicochemical characteristics, mechanical properties, rheology, and stability.
Main Results:
- Microemulsions can penetrate the skin's stratum corneum, aiding drug delivery.
- Incorporating microemulsions into viscous gel bases addresses viscosity limitations.
- Microemulsion-based gels demonstrate potential for controlled topical drug delivery, minimizing toxicity and erratic absorption.
Conclusions:
- Microemulsion-based viscous gels represent a promising advancement for topical and transdermal drug delivery.
- These systems offer improved physicochemical and mechanical properties for pharmaceutical applications.
- Further exploration of these gels can lead to safer and more effective drug delivery strategies.
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