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Psoriasin, a multifunctional player in different diseases
Jinjing Jia, Qiqi Duan, Jiaqi Guo
1Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China. zenyan66@126.com.
Current Protein & Peptide Science
|December 4, 2014
Summary
Psoriasin (S100A7) is a versatile protein involved in numerous cellular functions and immune responses. Its altered expression is linked to various diseases, highlighting its potential as a biomarker and therapeutic target.
Area of Science:
- Biochemistry
- Molecular Biology
- Immunology
Background:
- Psoriasin (S100A7) is a member of the S100 protein family, initially identified in psoriatic keratinocytes.
- It plays roles in intracellular and extracellular processes, including cell regulation, immune responses, and inflammation.
Purpose of the Study:
- To review the diverse functions of psoriasin (S100A7).
- To elucidate the mechanisms underlying psoriasin's actions.
- To discuss its potential as a biomarker and therapeutic target for various diseases.
Main Methods:
- Literature review of studies on psoriasin (S100A7).
- Analysis of research on psoriasin's involvement in cellular pathways and disease association.
Main Results:
- Psoriasin (S100A7) regulates calcium homeostasis, cell proliferation, differentiation, apoptosis, invasion, motility, cytoskeleton dynamics, and immune responses.
- Altered psoriasin expression is associated with inflammatory disorders, immune diseases, and tumors.
- Psoriasin exerts functions via intracellular and extracellular pathways, influencing gene expression.
Conclusions:
- Psoriasin (S100A7) is a multifunctional protein with significant implications in health and disease.
- Its diverse roles and association with pathological conditions suggest its potential as a valuable biomarker and therapeutic target.
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