Related Experiment Video
Updated: Apr 20, 2026
06:04
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
1.7K
MSP: an emerging player in metabolic syndrome
Jieyi Li1, Dipanjan Chanda2, Ronit Shiri-Sverdlov1
1Department of Molecular Genetics, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Cytokine & Growth Factor Reviews
|December 4, 2014
Summary
Macrophage Stimulating Protein (MSP) regulates inflammation and hepatic metabolism. This review highlights MSP
Area of Science:
- Biochemistry
- Molecular Biology
- Immunology
Background:
- Macrophage Stimulating Protein (MSP), also known as Hepatocyte Growth Factor-like protein (HGFL), is a secreted protein.
- MSP functions as the ligand for the receptor tyrosine kinase Recepteur d'Origine Nantais (RON).
- MSP has been implicated in regulating peripheral tissue inflammation across various disease models.
Purpose of the Study:
- To review recent advances on the role of MSP in metabolic syndrome.
- To explore the therapeutic potential of MSP in metabolic disorders.
- To highlight MSP's dual role in metabolic homeostasis and inflammation suppression.
Main Methods:
- Literature review of recent scientific advances.
- Analysis of MSP's function in metabolic and inflammatory pathways.
- Synthesis of evidence supporting MSP's therapeutic applications.
Main Results:
- MSP plays a significant role in regulating hepatic lipid and glucose metabolism.
- MSP is crucial for maintaining metabolic homeostasis.
- MSP demonstrates potent anti-inflammatory properties.
Conclusions:
- MSP is a key regulator of metabolic processes and inflammation.
- Recent evidence strongly supports the therapeutic potential of MSP for metabolic syndrome.
- Targeting the MSP/RON pathway may offer novel treatment strategies for metabolic and inflammatory diseases.
More Related Videos
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
12.4K
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
11.3K
Related Concept Videos
01:26Type II Diabetes I: Introduction
2
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
2
01:24Obesity
1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
01:24Type II Diabetes II: Pathophysiology
2
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
2
01:24Overview of Lipid Metabolism
7.2K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
7.2K
01:19Overview of Carbohydrate Metabolism
4.8K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
4.8K
01:21Hyperosmolar Hyperglycemic State
2
Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
2