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Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
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When to biopsy seminal vesicles.

J Panach-Navarrete1, F García-Morata1, J A Hernández-Medina1

  • 1Servicio de Urología, Hospital Clínico Universitario de Valencia, Valencia, España.

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|December 4, 2014
PubMed
Summary

Predicting seminal vesicle infiltration in prostate cancer is crucial for treatment. A PSA level of 20 ng/ml or higher, suspicious rectal exams, and a non-preserved prostatoseminal angle strongly indicate seminal vesicle involvement.

Keywords:
BiopsiaBiopsyCáncer de próstataProstate cancerSeminal vesiclesVesículas seminales

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Seminal vesicle involvement in prostate cancer impacts prognosis and treatment decisions.
  • Accurate prediction of seminal vesicle infiltration is essential for guiding biopsy indications.

Purpose of the Study:

  • To identify predictive factors for seminal vesicle infiltration during prostate biopsy.
  • To determine when seminal vesicle biopsy is indicated based on predictive markers.

Main Methods:

  • Retrospective observational study of 466 patients undergoing seminal vesicle biopsy.
  • Analysis of variables including PSA level, PSA density, prostate volume, rectal examination findings, and prostatoseminal angle.
  • Univariate and multivariate analyses to assess relationships with seminal vesicle involvement.

Main Results:

  • Seminal vesicle infiltration was observed in 8.8% of patients.
  • Higher PSA levels, increased PSA density, lower prostate volume, suspicious rectal exams, and absent prostatoseminal angle preservation were associated with infiltration.
  • Multivariate analysis indicated that a non-preserved prostatoseminal angle (OR 5.19), PSA >19.60 ng/dL (OR 4.65), and suspicious rectal exam (OR 2.95) significantly predicted infiltration.

Conclusions:

  • Seminal vesicle involvement in prostate cancer is associated with elevated PSA levels (≥20 ng/ml), suspicious rectal examinations, and lack of prostatoseminal angle preservation.
  • These factors can aid in determining the need for seminal vesicle biopsy.