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Synthetic immunology: modulating the human immune system.

Barbara Geering1, Martin Fussenegger2

  • 1Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.

Trends in Biotechnology
|December 4, 2014
PubMed
Summary

Synthetic immunology engineers biological devices to rationally manipulate immune responses for therapeutic benefit. This approach aims to treat immune disorders and improve pathogenic conditions using engineered proteins and cells.

Keywords:
adoptive immunotherapyantibody derivativeantibody mimeticautologous hematopoietic stem cell transplantationprotein engineeringsynthetic biology

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Area of Science:

  • Immunology
  • Biotechnology
  • Synthetic Biology

Background:

  • Humans have historically modulated the immune system.
  • Advances in immunology and biotechnology enable precise immune manipulation.
  • Synthetic immunology offers rational control over immune responses.

Purpose of the Study:

  • To review therapeutic strategies based on synthetic immunology.
  • To explore methods for ameliorating immune disorders.
  • To discuss exploiting immune cell functions for therapeutic gain.

Main Methods:

  • Highlighting synthetic proteins in preclinical and clinical trials.
  • Summarizing studies on engineered immune cells.
  • Discussing future therapeutic concepts in synthetic immunology.

Main Results:

  • Synthetic proteins show promise in preclinical and clinical investigations.
  • Engineered immune cells are being explored for therapeutic applications.
  • The field is advancing towards novel therapeutic concepts.

Conclusions:

  • Synthetic immunology provides a framework for engineering biological devices to control immune responses.
  • Therapeutic applications include treating immune system disorders and enhancing disease management.
  • Future directions involve innovative synthetic protein and cell-based therapies.