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Published on: September 28, 2022
Pyrrole alkaloids from the fruits of Morus alba
Seon Beom Kim1, Bo Yoon Chang2, Bang Yeon Hwang1
1College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea.
Abstract:
Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity.
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