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An alkene, such as propene, reacts with bromine in the presence of water to yield a halohydrin. Halohydrins contain a halogen and a hydroxyl group attached to adjacent carbons. When the halogen is bromine, it is called a bromohydrin, while a chlorohydrin has chlorine as the halogen.

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Updated: Apr 20, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

Halogen bonding in supramolecular synthesis.

Christer B Aakeröy¹, Christine L Spartz

¹Department of Chemistry, Kansas State University, Manhattan, KS, 66506, USA.

Topics in Current Chemistry

|December 4, 2014

Summary

Halogen bonds enable advanced supramolecular synthesis by allowing multiple components to assemble predictably. This research explores using halogen bonds for designing complex molecular architectures and co-crystals.

Area of Science:

Supramolecular Chemistry
Crystal Engineering
Organic Synthesis

Background:

Supramolecular synthesis is often restricted to one-pot reactions due to the reversible nature of non-covalent bonds.
Developing methods to control the assembly of multiple components is crucial for advancing supramolecular synthesis.
Halogen bonds offer unique properties like strength and directionality, making them promising for supramolecular strategies.

Purpose of the Study:

To investigate the potential of halogen bonds as key components in versatile supramolecular synthetic strategies.
To explore halogen-bond driven crystal engineering for assembling specific architectures in molecular solids.
To examine the utility of halogen bonds in synthesizing co-crystals and their compatibility with hydrogen bonds.

Main Methods:

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Last Updated: Apr 20, 2026

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Published on: February 15, 2016

Detailed description of several halogen-bond driven crystal engineering strategies.
Analysis of halogen bond utility in the synthesis of co-crystals.
Examination of structural compatibility and competition between halogen and hydrogen bonds in supramolecular synthesis.

Main Results:

Demonstration of halogen bonds enabling the assembly of specific architectures in molecular solids.
Successful application of halogen bonds in the synthesis of co-crystals.
Insights into the interplay between halogen and hydrogen bonds during supramolecular assembly.

Conclusions:

Halogen bonds are effective tools for overcoming limitations in supramolecular synthesis, enabling predictable assembly.
Crystal engineering strategies driven by halogen bonds facilitate the construction of complex molecular architectures.
Understanding halogen- and hydrogen-bond interactions is key to designing advanced supramolecular systems.