Related Experiment Video
Updated: Apr 20, 2026

11:17
Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
Published on: November 25, 2025
966
Internet-based cognitive behavioural self-help for premenstrual syndrome: study protocol for a randomised controlled
Johanna N Kues1, Carolyn Janda, Maria Kleinstäuber
1Department of Psychology, Division of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Gutenbergstr, 18, 35032 Marburg, Germany. kuesj@uni-marburg.de.
Trials
|December 4, 2014
Summary
This study evaluates internet-based cognitive behavioural therapy for premenstrual syndrome (PMS). The self-help treatment shows promise for reducing PMS-related impairment and improving quality of life for affected women.
Area of Science:
- Psychiatry and Psychology
- Women's Health
- Digital Therapeutics
Background:
- Severe premenstrual symptoms, or premenstrual syndrome (PMS), affect 3-8% of reproductive-age women.
- PMS significantly impairs daily functioning and quality of life, comparable to dysthymic disorders.
- Many women with PMS are untreated or unsatisfied with current treatment options.
Purpose of the Study:
- To evaluate the efficacy of a novel internet-based cognitive behavioural self-help treatment for premenstrual syndrome.
- To address the gap in rigorously tested psychotherapeutic interventions for PMS.
Main Methods:
- A randomized controlled trial design was employed.
- Participants completed a symptom diary and telephone interview for diagnosis.
- Eligible women were randomized to an 8-week internet-delivered cognitive behavioural therapy (iCBT) intervention or a wait-list control group.
Main Results:
- The primary outcome was measured using the Premenstrual Syndrome Impairment Measure.
- Secondary outcomes included coping strategies, social support, relationship quality, and perceived stress.
- Data were collected at pre-treatment, post-treatment, and 6-month follow-up.
Conclusions:
- This is the first study to investigate internet-based cognitive behavioural therapy for premenstrual syndrome.
- The iCBT program offers a scalable approach to managing PMS, addressing high prevalence and treatment limitations.

