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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Apr 20, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Pasteurella multocida infection in solid organ transplantation.

Eric S Christenson1, Haitham M Ahmed1, Christine M Durand1

  • 1Johns Hopkins University, Department of Medicine, Baltimore, MD, USA.

The Lancet. Infectious Diseases
|December 4, 2014
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Summary
This summary is machine-generated.

Fulminant Pasteurella multocida sepsis occurred in an immunocompromised renal transplant patient due to cat exposure. This rare infection highlights the need to consider animal-associated pathogens in immunosuppressed individuals with severe sepsis.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Transplantation

Background:

  • Pasteurella multocida is a zoonotic bacterium typically causing mild infections.
  • Immunocompromised individuals, particularly transplant recipients, are at higher risk for severe Pasteurella multocida infections.
  • Close contact with domestic animals like cats and dogs is a known risk factor for Pasteurella multocida transmission.

Observation:

  • A 66-year-old renal transplant recipient developed fulminant sepsis.
  • The patient had close contact with household pets, including a cat.
  • The sepsis was attributed to Pasteurella multocida, potentially from cat saliva via skin ulcers.

Findings:

  • The patient experienced rapid clinical deterioration with cardiopulmonary failure.
  • Despite treatment, the infection was fatal.
  • This case underscores the potential for severe Pasteurella multocida infections in immunocompromised hosts.

Implications:

  • Clinicians should consider Pasteurella multocida in immunocompromised patients with severe infections, especially with a history of animal exposure.
  • Early recognition and appropriate antibiotic therapy are crucial for managing Pasteurella multocida sepsis.
  • Understanding the zoonotic potential of Pasteurella multocida is vital for public health, particularly for organ transplant recipients.