Histiocytic typhlocolitis in two colony Beagle dogs
Francisco R Carvallo1, Roy Kerlin2, Claudine Fredette3
1California Animal Health and Food Safety Laboratory, 105 West Central Avenue, San Bernardino, CA 92408, USA.
Summary
Histiocytic ulcerative colitis, a gastrointestinal condition, was diagnosed in two Beagle dogs. Escherichia coli strain LF82, linked to Crohn's disease, was identified as a potential cause.
Area of Science:
- Veterinary Pathology
- Microbiology
- Gastroenterology
Background:
- Histiocytic ulcerative colitis (HUC) is a recognized syndrome in several dog breeds.
- Clinical signs include loose stools and fecal blood.
- This condition is important to differentiate from drug-induced findings in toxicity studies.
Purpose of the Study:
- To report a case of histiocytic ulcerative colitis in Beagle dogs.
- To identify potential causative agents.
- To highlight diagnostic considerations in nonclinical studies.
Main Methods:
- Histologic evaluation of large intestine sections.
- Immunohistochemistry for bacterial identification.
- 16S ribosomal RNA gene sequencing for bacterial strain confirmation.
Main Results:
- Histologic confirmation of histiocytic ulcerative colitis in two Beagle dogs.
- Identification of Escherichia coli strain LF82 in one affected dog.
- E. coli LF82 is known to be involved in Crohn's disease pathogenesis.
Conclusions:
- Escherichia coli strain LF82 may play a role in the pathogenesis of histiocytic ulcerative colitis in Beagle dogs.
- This finding has implications for differentiating spontaneous disease from experimental findings.
- Further research into the role of specific bacterial strains in canine colitis is warranted.
