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Updated: Apr 20, 2026
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Polybrominated diphenyl ethers in human placenta associated with neonatal physiological development at a typical
Long Xu1, Xia Huo, Yuling Zhang
1Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou 515041, China.
Abstract:
Our aim of this study was to characterize the exposure pattern of polybrominated diphenyl ethers(PBDEs) in human placenta and assess their potential effects on neonates. Placenta samples were obtained from a typical e-waste area in Guiyu and a reference area in Haojiang, China. The median ΣPBDE concentration was 32.25 ng/g lipid weight (lw) in placenta samples from Guiyu, and 5.13 ng/g lw from Haojiang. BDE-209 predominated in placenta samples, followed by BDE-28, -47, -99 -153, -183. Residence in Guiyu contributed the most to elevated PDBE levels. Neonatal physiological indices, including bodymass index (BMI), Apgar 1 score and head circumference, were reduced in Guiyu group. No significant difference was found in neonatal weight between the two groups, but neonatal body length in Guiyu was increased. Our data suggest prenatal exposure to PBDEs is high at the e-waste recycling area, and may lead to adverse physiological development in the fetus.
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