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Updated: Apr 20, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
A genetic anomaly of oriented collagen biosynthesis and cross-linking: Keratoconus
J L Bourges1, A M Robert2, L Robert2
1Centre d'ophtalmologie HUPC, hôpital Hôtel-Dieu, Assistance publique-Hôpitaux de Paris, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France; Faculté de médicine Paris Descartes, université Sorbonne Paris Cité, 15, rue de l'École-de-Médecine, 75006 Paris, France.
Abstract:
Oriented collagen biosynthesis is one of the major mechanisms involved in tissue and organ formation during development. Corneal biogenesis is one example. Defects in this process lead to anomalies in tissue structure and function. The transparency of cornea and its achievement are a good example as well as its pathological modifications. Keratoconus is one example of this type of pathologies, involving also inappropriate cross-linking of collagen fibers. Among the tentatives to correct this anomaly, the riboflavin-potentiated UV-cross-linking (CXL) of keratoconus corneas appears clinically satisfactory, although none of the experiments and clinical results published prove effective cross-linking. The published results are reviewed in this article.
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