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Peritoneum

Peritoneum

The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
Anatomy of the Peritoneum
The peritoneum is divided into two layers: the parietal peritoneum and the visceral...

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Primary peritoneal ependymoma.

Tyler P Verdun¹, David A Owen¹

¹Division of Anatomical Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

Pathology, Research and Practice

|December 4, 2014

Summary

Extra-axial ependymomas are rare tumors outside the brain. This case details an intraperitoneal ependymoma recurring over 24 years, highlighting its unusual presentation and behavior.

Area of Science:

Oncology
Neuropathology

Background:

Extra-axial ependymomas are rare tumors originating outside the central nervous system.
Most extra-axial ependymomas exhibit benign clinical behavior.

Observation:

An elderly woman presented with an intraperitoneal ependymoma.
The tumor recurred twice over a 24-year period following initial surgical excision.
Histological examination revealed consistent features, including rosettes and perivascular pseudorosettes, at each recurrence.

Findings:

Immunohistochemistry demonstrated strong positivity for glial fibrillary acidic protein, estrogen receptors, CAM 5.2, and CD99.
Staining for pankeratin was weak, while epithelial membrane antigen (EMA) and S-100 were negative.
Ultrastructural analysis confirmed neuroectodermal features, such as filamentous cytoplasm and intercellular bridges.

Keywords:

Ependymoma Extra-axial Peritoneum

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Implications:

The absence of central nervous system or para-spinal lesions suggests a spontaneous origin of the intraperitoneal ependymoma.
This case underscores the potential for late recurrence and highlights the importance of long-term surveillance for such rare tumors.
The findings contribute to understanding the diverse clinical and pathological spectrum of extra-axial ependymomas.