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Conformational changes in the T cell receptor differentially determine T cell subset development in mice

Raquel Blanco1, Aldo Borroto1, Wolfgang Schamel2

  • 1Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Science Signaling
|December 4, 2014
PubMed
Summary

T-cell development relies on T cell receptor (TCR) conformational changes. Mutations in CD3ε, a TCR component, reveal Nck adaptor protein

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