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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Mid-term outcomes in patients implanted with cardiac resynchronization therapy

Sung Ho Lee1, Seung-Jung Park2, June Soo Kim2

  • 1Division of Cardiology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Journal of Korean Medical Science
|December 4, 2014
PubMed

Insights

Cardiac resynchronization therapy (CRT) significantly improved heart failure symptoms and echocardiographic measures in Korean patients. CRT reduced heart failure hospitalizations and mortality, demonstrating its effectiveness in managing advanced heart failure.

Area of Science:

  • Cardiology
  • Medical Devices

Background:

  • Heart failure (HF) management often involves addressing cardiac dyssynchrony.
  • Cardiac resynchronization therapy (CRT) is a treatment option for selected HF patients.

Purpose of the Study:

  • To evaluate the clinical outcomes and echocardiographic changes in Korean patients with heart failure who received CRT.
  • To assess the impact of CRT on morbidity, mortality, and heart failure hospitalizations.

Main Methods:

  • A retrospective study of 47 patients with implanted CRT in Korea (October 2005 - May 2013).
  • Primary endpoint: combined incidence of heart failure hospitalization, heart transplantation, or death.
  • Echocardiographic parameters and New York Heart Association (NYHA) classification were assessed pre- and post-CRT.

Main Results:

  • The primary composite endpoint occurred in 21.3% of patients over a median follow-up of 17.5 months.
  • CRT demonstrated significant improvements in NYHA class, QRS duration, left ventricular volumes, and ejection fraction at 6 months.
  • One-year and three-year freedom rates from heart failure hospitalization were 90.1% and 69.4%, respectively.

Conclusions:

  • CRT effectively improved symptoms and cardiac function in desynchronized heart failure patients.
  • CRT was associated with low mortality and reduced heart failure hospitalizations in this Korean cohort.

Keywords:
Cardiac Resynchronization TherapyEchocardiographyHeart Failure

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