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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Labeling DNA Probes03:31

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
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PET probes beyond (18)F-FDG.

Lei Jiang1, Yingfeng Tu2, Hongcheng Shi3

  • 1Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China. ; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford Cancer Institute, Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA 94305, USA.

Journal of Biomedical Research
|December 4, 2014
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) imaging is advancing beyond (18)F-FDG probes. This review explores new PET agents for oncology, neurology, and cardiology, highlighting personalized medicine trends.

Keywords:
PETmolecular probespersonalized medicine

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Positron emission tomography (PET) is a key medical imaging modality, especially in oncology.
  • (18)F-fluorodeoxyglucose ((18)F-FDG) is the most common PET tracer but has limitations.
  • There is a significant need for novel PET probes with improved specificity and affinity.

Purpose of the Study:

  • To review PET probes beyond (18)F-FDG for clinical applications.
  • To discuss emerging PET imaging agents in oncology, neurology, and cardiology.
  • To explore the future of PET probe development for personalized medicine.

Main Methods:

  • Literature review of existing and emerging PET imaging probes.
  • Analysis of clinical applications in oncology, neurology, and cardiology.
  • Discussion of trends in the development of PET probes for personalized diagnostics.

Main Results:

  • Several PET probes beyond (18)F-FDG are available for patient imaging.
  • These novel probes offer enhanced specificity and affinity for various diseases.
  • The development of targeted PET agents is crucial for personalized medicine.

Conclusions:

  • New PET probes are expanding diagnostic capabilities beyond (18)F-FDG.
  • These advancements are vital for precision medicine in oncology, neurology, and cardiology.
  • Future research focuses on developing highly specific PET agents for tailored patient care.