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Published on: November 8, 2024
Slow coronary flow phenomenon and increased platelet volume indices
Mir Hossein Seyyed-Mohammadzad1, Kamal Khademvatani1, Abdollah Kerachian1
1Department of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran.
Insights
Platelet volume indices like mean platelet volume (MPV) are higher in patients with slow coronary flow (SCF). These indices are linked to the presence and severity of SCF, indicating potential diagnostic value.
Area of Science:
- Cardiology
- Hematology
- Diagnostic Markers
Background:
- Slow coronary flow (SCF) is a condition affecting coronary artery blood flow.
- Platelet indices, including mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR), reflect platelet activation and function.
- The association between platelet indices and SCF requires further investigation.
Purpose of the Study:
- To investigate the relationship between MPV, PDW, P-LCR, and SCF.
- To determine if platelet volume indices can predict the presence and extent of SCF.
Main Methods:
- A case-control study involving 80 participants undergoing coronary angiography.
- Participants were divided into SCF (n=50) and normal coronary flow (NCF) (n=30) groups.
- Baseline characteristics and laboratory data, including platelet indices, were collected.
Main Results:
- MPV, PDW, and P-LCR were significantly higher in the SCF group compared to the NCF group.
- Higher platelet volume indices were observed in patients with three SCF arteries but not with one.
- MPV and P-LCR were identified as independent predictors of SCF in multivariate analysis.
Conclusions:
- Platelet volume indices (MPV, PDW, P-LCR) are associated with the presence of SCF.
- These indices may serve as potential biomarkers for evaluating the extent of slow coronary flow.
Background And Objectives:
We sought to determine the relationship between mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) with slow coronary flow (SCF).
Subjects And Methods:
Eighty participants who underwent coronary angiography were divided into two groups, 50 participants with SCF as case group, and 30 with normal coronary flow (NCF) as control group. Baseline characteristics and laboratory data were collected before angiography.
Results:
Platelet volume indices MPV (10.8±1.2 fL), PDW (14.5±2.2 fL), and P-LCR (30.5±8.1%) in the SCF group were significantly (p<0.05) higher than those (10.1±0.9 fL, 13.2±1.8 fL, and 26.8±6.8%, respectively) in the NCF group. The patients with three SCF arteries had significantly higher platelet volume indices compared to those with NCF arteries; however, the patients with one SCF artery did not. Based on linear regression model, MPV, PDW, and P-LCR were independent predictors of mean infarction frame counting (TFC). In multivariate analysis, MPV {odds ratio (OR)=32.393, 95% confidence interval (CI)=1.189-882.606, p=0.039} and P-LCR (OR=0.566, 95% CI=0.330-0.937, p=0.028) were independent predictors of SCF.
Conclusion:
Platelet volume indices MPV, PDW, and P-LCR were associated with both the presence and extent of SCF.
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