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The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma

Claudia V Andreu-Vieyra1, James R Berenson2

  • 1Oncotherapeutics, West Hollywood, CA, USA.

Therapeutic Advances in Hematology
|December 4, 2014
PubMed

Insights

Panobinostat, a histone deacetylase inhibitor (HDACi), shows promise for treating multiple myeloma. This review covers its use in combination therapy and ongoing clinical trials evaluating its safety and efficacy.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Panobinostat is an investigational histone deacetylase inhibitor (HDACi).
  • It has demonstrated preclinical promise as an antimultiple myeloma agent.
  • Multiple myeloma is a cancer of plasma cells.

Purpose of the Study:

  • To discuss the rationale for using panobinostat in combination therapy for multiple myeloma.
  • To provide an overview of clinical trials investigating panobinostat for multiple myeloma treatment.

Main Methods:

  • Review of preclinical data.
  • Analysis of ongoing and recent clinical trials.
  • Evaluation of safety and efficacy data.

Main Results:

  • Panobinostat exhibits antimultiple myeloma activity in preclinical studies.
  • Clinical trials are actively assessing its safety and efficacy in combination regimens.
  • Further data is needed to establish optimal use in multiple myeloma treatment.

Conclusions:

  • Panobinostat holds potential as a component of combination therapy for multiple myeloma.
  • Ongoing clinical trials are crucial for determining its role in patient treatment.
  • The efficacy and safety profile of panobinostat warrants continued investigation.
Keywords:
histone deacetylase inhibitormultiple myelomapanobinostat

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