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Updated: Apr 20, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Combining the Petasis 3-component reaction with multiple modes of cyclization: a build/couple/pair strategy for the
Thomas Flagstad1, Mette R Hansen, Sebastian T Le Quement
1Department of Chemistry, Technical University of Denmark , DK-2800 Kgs. Lyngby, Denmark.
Abstract:
A build/couple/pair strategy for the synthesis of complex and densely functionalized small molecules is presented. The strategy relies on synthetically tractable building blocks (build), that is, diversely substituted hydrazides, α-hydroxy aldehydes, and boronic acids, which undergo Petasis 3-component reactions (couple) to afford densely functionalized anti-hydrazido alcohols. The resulting scaffolds can subsequently be converted via chemoselective cyclization reactions (pair), including intramolecular Diels-Alder or Ru-alkylidene catalyzed ring-closing metathesis, into sets of structurally diverse heterocycles in good yields in only 3-4 steps.
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