Italian Diffuse/Multivessel Disease ABSORB Prospective Registry (IT-DISAPPEARS). Study design and rationale

Area of Science:

• Cardiovascular Medicine
• Interventional Cardiology
• Biomaterials Science

Background:

• The Absorb Bioresorbable Vascular Scaffold System (Absorb BVS) offers temporary scaffolding and drug delivery for coronary artery disease.
• It presents a potential alternative to metallic stents, with evidence suggesting comparable results to second-generation stents in low-risk patients.
• However, its performance in complex coronary artery disease remains less understood.

Purpose of the Study:

• To investigate the procedural and clinical performance of Absorb BVS in patients with complex coronary artery disease.
• To evaluate Absorb BVS in patients with long (>24mm) single-vessel or multivessel coronary disease.
• To assess the safety and efficacy of Absorb BVS in a high-risk population.

Main Methods:

• The IT-DISAPPEARS study will enroll 1000 patients across 50 Italian centers.
• Patients will have either stable or acute coronary syndromes, including long or multivessel disease.
• Follow-up will extend to 5 years, with a primary endpoint of major adverse cardiac events at 1 year.

Main Results:

• Primary endpoint: cumulative hierarchical incidence of major adverse cardiac events (cardiac death, MI, TLR) at 1 year.
• Secondary evaluations include efficacy and safety parameters.
• Detailed assessment of dual antiplatelet therapy duration and interruption.

Conclusions:

• The IT-DISAPPEARS study aims to provide the first global evidence on Absorb BVS performance in high-risk, diffuse coronary disease.
• Findings will inform the use of Absorb BVS in complex patient subsets.
• This research could establish Absorb BVS as a viable option for challenging cases.