Related Experiment Video

Updated: Apr 20, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

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Emerging treatments for amyloidosis

Rabya H Sayed1, Philip N Hawkins2, Helen J Lachmann1

  • 11] National Amyloidosis Centre, UCL Medical School, Royal Free Hospital, London, UK [2] UCL Centre for Nephrology, UCL Medical School, Royal Free Hospital, London, UK.

Kidney International
|December 4, 2014
PubMed

Insights

New targeted therapies are emerging for amyloidosis, a disease caused by protein misfolding that can lead to organ failure. These novel treatments, including protein stabilizers and immunotherapy, are now in clinical trials.

Area of Science:

  • Biochemistry
  • Pathology
  • Pharmacology

Background:

  • Amyloidosis is a group of diseases characterized by protein misfolding and subsequent amyloid deposition.
  • These conditions often lead to organ failure and have historically had limited treatment options and poor prognoses.

Purpose of the Study:

  • To review emerging targeted therapeutic approaches for amyloidosis.
  • To highlight treatments currently under investigation in clinical trials.

Main Methods:

  • Review of current scientific literature and clinical trial data.
  • Categorization of emerging therapies based on their mechanism of action.

Main Results:

  • Identification of several novel therapeutic strategies including protein stabilizers, fibrillogenesis inhibitors, fibril disruptors, and immunotherapy.
  • Confirmation that these approaches are actively being assessed in clinical trials.

Conclusions:

  • Targeted therapies represent a significant advancement in the treatment of amyloidosis.
  • Ongoing clinical trials are evaluating the efficacy and safety of these novel approaches, offering new hope for patients.

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