Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...

Psychosis: Goals of Pharmacotherapy

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The effect of cumulative trauma load on suicide risk and thoughts in trauma-exposed youth over two years.

Journal of affective disorders·2026

Same author

Corrigendum to "Establishing a training plan and estimating inter-rater reliability across the multi-site Texas Childhood Trauma Research Network" [Psychiatry Research 323 (2023) 115168].

Psychiatry research·2026

Same author

Corrigendum to "Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma" [J Mood Anxiety Disord 10C (2025) 100117].

Journal of mood and anxiety disorders·2026

Same author

History of interpersonal trauma exposure is a robust risk factor for alcohol and substance use disorders during adolescence.

Journal of psychiatric research·2025

Same author

Factors associated with interpersonal retraumatization in children and adolescents: A prospective study.

Psychiatry research·2025

Same author

Exploring resource profiles among trauma exposed youth: An identity-focused, cultural, and person-centered approach.

Journal of affective disorders·2025

Search research articles

Related Experiment Video

Updated: Apr 20, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Timely topics in pediatric psychiatry.

Karen Dineen Wagner¹

¹kwagner@psychiatrist.com.

The Journal of Clinical Psychiatry

|December 4, 2014

Summary

Inflammation may play a role in child and adolescent depression and suicidality. This review examines links between inflammatory processes, medical conditions, and mental health in young people.

Area of Science:

Child and adolescent psychiatry
Neuroinflammation
Pediatric mental health

Background:

Reviews the role of inflammation in child and adolescent depression and suicidality.
Examines glutamatergic dysregulation in pediatric psychiatric disorders.
Investigates predictors of bipolar disorder in children with attention-deficit/hyperactivity disorder (ADHD).

Discussion:

Highlights the growing interest in inflammation's impact on psychiatric disorders.
Discusses the continuum between obsessive-compulsive personality disorder (OCPD) and obsessive-compulsive disorder (OCD).
Explores the relationship between inflammatory processes, medical conditions, and mental health outcomes.

Key Insights:

Inflammatory processes are increasingly recognized as relevant to pediatric mental health.

More Related Videos

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

Related Experiment Videos

Last Updated: Apr 20, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

Medical conditions may influence inflammation, impacting depression and suicidality in youth.

Understanding these links is crucial for developing targeted interventions.

Outlook:

Further research is needed to elucidate the precise mechanisms of inflammation in pediatric mental health.
Potential for novel therapeutic targets focusing on anti-inflammatory strategies.
Importance of a holistic approach considering medical and psychiatric comorbidities.