Higher adenoma detection rates with endocuff-assisted colonoscopy - a randomized controlled multicenter trial

Area of Science:

• Gastroenterology
• Endoscopy
• Colorectal Cancer Screening

Background:

• Colorectal cancer (CRC) is a significant health concern.
• Early detection of adenomas is crucial for CRC prevention.
• Standard colonoscopy has limitations in detecting all colorectal polyps.

Purpose of the Study:

• To compare adenoma detection rates (ADR) between Endocuff-assisted (EC) colonoscopy and standard colonoscopy (SC).
• To evaluate the safety and efficacy of the Endocuff device in colonoscopy.

Main Methods:

• A randomized prospective multicenter trial involving 500 patients across four German academic endoscopy units.
• Patients were allocated to either EC or SC.
• The primary outcome was the adenoma detection rate (ADR).

Main Results:

• Endocuff-assisted colonoscopy significantly increased ADR compared to standard colonoscopy (35.4% vs. 20.7%, p<0.0001).
• Significantly more sessile polyps were detected with EC.
• Procedure and withdrawal times were similar; no major adverse events were reported.

Conclusions:

• Endocuff-assisted colonoscopy is a safe and effective method that increases adenoma detection rates by 14.7%.
• The device is easy to handle and may help reduce the incidence of colorectal interval carcinomas.