Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis
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Published on: May 26, 2023
Hyung Seok Lee1, Hye Sun Lee2, Hyo Eun Lee1
1Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Introduction:
Predictive factors for myasthenic crisis after transsternal thymectomy have been reported, but little is known about myasthenic crisis after videoscopic thymectomy (MCAVT).
Methods:
We investigated 146 myasthenia gravis patients who underwent videoscopic thymectomy.
Results:
Patients with MCAVT had a lower forced vital capacity (FVC) (2.1 vs. 3.0 L, P < 0.001) than those without. Low-frequency repetitive nerve stimulation showed decremental responses of the orbicularis oculi (47.1% vs. 18.1%, P = 0.001) and nasalis muscles (54.1% vs. 21.4%, P < 0.001), which were more pronounced in patients with MCAVT than those without. According to multivariate analysis, FVC (OR 0.144, 95% confidence interval [CI], 0.044-0.479, P = 0.002) and decremental response of orbicularis oculi (odds ratio, 1.029; 95% CI, 1.001-1.058, P = 0.044) were independently associated with MCAVT.
Conclusions:
FVC and decremental response of orbicularis oculi were associated with MCAVT.
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