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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Floating dosage forms aim for prolonged gastric residence time for enhanced oral drug delivery.
  • Hydrophobic drugs often exhibit slow and incomplete release from gastric systems, leading to reduced absorption and drug wastage.
  • Developing advanced delivery systems is crucial for optimizing the release of challenging hydrophobic drugs.

Purpose of the Study:

  • To develop a spray-coated floating microcapsule system for controlled and enhanced release of hydrophobic drugs.
  • To encapsulate fenofibrate and piroxicam into coating layers to modulate drug release rates.
  • To create a multi-drug system incorporating both hydrophilic and hydrophobic drugs for sustained release.

Main Methods:

  • Fabrication of spray-coated floating microcapsules using poly(caprolactone) (PCL) and polyethylene glycol.
  • Encapsulation of fenofibrate, piroxicam, and metformin HCl into microcapsule coating layers and/or hollow cavities.
  • Evaluation of drug release profiles, buoyancy, and sustained release characteristics in simulated gastric fluid.

Main Results:

  • Fenofibrate incorporated into PCL coating showed complete and sustained release for up to 8 hours.
  • Simultaneous encapsulation of metformin HCl and fenofibrate resulted in complete and sustained release of both drugs.
  • Piroxicam exhibited a double-profile release (burst followed by sustained) when loaded in dual coating layers.
  • The microcapsules demonstrated excellent buoyancy and controlled, sustained drug release.

Conclusions:

  • Spray-coated floating microcapsules offer a versatile platform for tuning drug release rates of hydrophobic and hydrophilic drugs.
  • This system effectively enhances drug absorption and minimizes drug wastage by providing controlled and sustained release.
  • The developed microcapsules show significant potential as a rate-controlled oral drug delivery system for various therapeutic applications.