Ten years cardiovascular risk estimation according to Framingham score and non HDL-cholesterol in blood donors
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Mabel Nora Graffigna1, Gabriela Berg2, Marta Migliano3
1Department of Diabetes and Lipid Metabolism, Society of Endocrinology and Metabolism, Buenos Aires, Argentina; Endocrinology Division, Carlos Durand Hospital, Buenos Aires, Argentina.
Insights
Individuals with metabolic syndrome (MS) and high non HDL-cholesterol have a significantly increased 10-year risk for cardiovascular disease (CVD). This study assessed CVD risk in Argentinean blood donors, highlighting MS as a key predictor.
Area of Science:
- Cardiology
- Preventive Medicine
- Epidemiology
Background:
- Cardiovascular disease (CVD) is a leading cause of death globally.
- Metabolic syndrome (MS) is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
Purpose of the Study:
- To assess the 10-year cardiovascular disease (CVD) risk in Argentinean blood donors using the Framingham score (ATP III updated).
- To evaluate the prevalence of metabolic syndrome (MS) in this population.
- To examine non HDL-cholesterol levels as an additional CVD risk factor.
Main Methods:
- A prospective, epidemiological, transversal study involving 585 volunteer blood donors over two years.
- Non HDL-cholesterol calculated as total cholesterol minus HDL-cholesterol.
- Cardiovascular disease (CVD) 10-year risk assessed using the Framingham score (ATP III updated).
Main Results:
- Metabolic syndrome (MS) prevalence was determined using ATP III and IDF criteria.
- Participants with MS had higher non HDL-cholesterol levels compared to those without MS (e.g., 178.3±48.0 mg/dl vs. 143.7±39.3 mg/dl by ATP III).
- Individuals with MS showed an odds ratio (OR) of 3.1 (95% CI: 2-5) for higher cardiovascular disease (CVD) risk per the Framingham score.
Conclusions:
- Metabolic syndrome (MS) is associated with a significantly elevated estimated 10-year risk for cardiovascular events.
- Elevated non HDL-cholesterol in individuals with MS further contributes to their increased cardiovascular risk.
- The Framingham risk score effectively identifies individuals with MS at higher risk for future cardiovascular events.
Unlabelled:
Cardiovascular disease (CVD) is currently the primary cause of morbidity and mortality.
Aims:
(1) Assess the 10 years risk for CVD in Argentinean blood donors, according to Framingham score (updated by ATP III), (2) evaluate the prevalence of the MS, (3) evaluate non HDL-cholesterol level in this population as other risk for CVD.
Materials And Methods:
A prospective, epidemiological, transversal study was performed to evaluate 585 volunteer blood donors for two years. Non HDL-C was calculated as total cholesterol minus HDL-C and we evaluated the 10 years risk for CVD according to Framingham score (updated by ATP III).
Results:
Metabolic syndrome prevalence was estimated according to ATP III and IDF criteria. Non HDL-C was (media±SD) 178.3±48.0 mg/dl in participants with MS and 143.7±39.3 mg/dl without MS (ATPIII) and 160.1±43.6 mg/dl in participants with MS and 139.8±43.1 mg/dl without MS (IDF). Participants with MS presented an OR of 3.1; IC 95% (2-5) of CVD according to de Framingham score.
Conclusion:
Individuals with MS and elevated non HDL-C are at a higher estimated risk for cardiovascular events in the next 10 years according to the Framingham risk score.
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