Related Experiment Video

Updated: Aug 12, 2026

Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
11:57

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Published on: March 28, 2014

On the GABAA receptor: a molecular modeling approach

M H Aprison1, K B Lipkowitz

  • 1Section of Applied and Theoretical Neurobiology, Indiana University School of Medicine, Indianapolis 46223.

Journal of Neuroscience Research
|June 1, 1989
PubMed
Summary

Bicuculline methobromide antagonizes GABA, an inhibitory neurotransmitter. Molecular modeling reveals shared attachment points with GABA agonists, suggesting bicuculline blocks channels via an extra charged atom.

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