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Related Experiment Video

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

Non-celiac gluten hypersensitivity.

Munish Ashat, Rakesh Kochhar

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation

|December 5, 2014

Summary

This summary is machine-generated.

Non-celiac gluten sensitivity (NCGS) causes digestive and other symptoms when gluten is consumed. This review explores NCGS pathology and offers a diagnostic approach for this distinct condition.

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Area of Science:

Gastroenterology
Clinical Medicine
Immunology

Background:

Non-celiac gluten sensitivity (NCGS) is increasingly recognized.
NCGS presents with gastrointestinal and extra-intestinal symptoms responsive to gluten withdrawal.
It is distinct from celiac disease and irritable bowel syndrome (IBS).

Purpose of the Study:

To review the current understanding of non-celiac gluten sensitivity.
To outline the pathological mechanisms involved in NCGS.
To propose a diagnostic algorithm for managing NCGS patients.

Main Methods:

Literature review of existing studies on non-celiac gluten sensitivity.
Analysis of clinical presentations and diagnostic challenges.
Synthesis of information on proposed pathophysiological pathways.

Main Results:

NCGS symptoms are subjective, leading to diagnostic difficulties.
NCGS is considered a separate entity from IBS.
The underlying pathology of NCGS remains largely unknown.

Conclusions:

NCGS is an important emerging clinical diagnosis.
Further research is needed to elucidate NCGS pathology.
A structured diagnostic approach can aid in managing NCGS.