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Capecitabine plus gemcitabine in thymic epithelial tumors: final analysis of a Phase II trial
Giovannella Palmieri1, Carlo Buonerba, Margaret Ottaviano
1Cancer Center for Rare Tumors of Campania & Medical Oncology Division, University Federico II of Naples, Naples, Italy.
Background:
A multi-institutional Phase II trial was initiated in 2005 to test the combination gemcitabine and capecitabine in patients with thymic epithelial malignancies (TETs).
Patients & Methods:
Patients with histologic confirmation of TET diagnosis by central review who had received >1 systemic chemotherapy treatment were included. Patients received oral capecitabine (650 mg/mq twice daily on days 1-14) and intravenous gemcitabine (1000 mg/mq on days 1 and 8 every 3 weeks).
Results:
Of the 30 patients included (18 men, 12 women; median age: 57 years, range: 48-61 years), the majority (73%) had thymoma, and the remaining thymic carcinoma. Eight patients developed grade 3-4 neutropenia. A total of 12 patients had a response. Median progression-free survival was 11 months (range: 6.5-16.5).
Conclusion:
Capecitabine and gemcitabine is highly active in TETs.
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