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Updated: Apr 20, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Advances in systemic therapies for metastatic castration-resistant prostate cancer

Manish K Pant1, Ahmed Abughaban, Jeanny B Aragon-Ching

  • 1Department of Medicine, Division of Hematology & Oncology, George Washington University Medical Center, 2150 Pennsylvania Avenue, NW Washington, DC 20037, USA.

Future Oncology (London, England)
|December 5, 2014
PubMed

Insights

Recent advances in treating metastatic castration-resistant prostate cancer (mCRPC) have improved patient outcomes. This review covers standard therapies and novel agents, including anti-androgens, chemotherapy, and immunotherapy, highlighting pivotal trial data.

Area of Science:

  • Oncology
  • Urology

Background:

  • Metastatic castration-resistant prostate cancer (mCRPC) treatment has seen significant evolution.
  • Standard therapies and novel agents are critical for managing advanced prostate cancer.

Purpose of the Study:

  • To review recent advances in the systemic treatment of prostate cancer.
  • To summarize pivotal trial data for various therapeutic classes.

Main Methods:

  • Literature review of standard therapies and recent advances.
  • Analysis of pivotal trial data for anti-androgen drugs, androgen-biosynthesis inhibitors, chemotherapy, immunotherapy, and bone-targeted agents.

Main Results:

  • The treatment landscape for mCRPC has rapidly evolved in the last five years.
  • Clinical, biochemical, and radiographic outcomes are improving with novel agents.

Conclusions:

  • Several promising novel agents are improving outcomes for men with mCRPC.
  • Continued research and application of new therapies are essential for advancing prostate cancer care.
Keywords:
abiraterone acetateandrogen deprivation therapychemotherapyenzalutamideimmunotherapymetastatic castration-resistant prostate cancerradiumzoledronic acid

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