Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants
Gloria Pelizzo1, Maria Chiara Mimmi2, Maurizio Ballico2
1a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
Background:
The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.
Methods:
Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.
Results:
Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.
Conclusions:
Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.
