Related Experiment Video
Updated: Apr 20, 2026

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
Published on: October 21, 2021
Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review
Désirée R M Seib1, Ana Martin-Villalba
1Division of Molecular Neurobiology, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Abstract:
New neurons are continuously generated and added to neural circuits in the adult brain. However, increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis. Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associated with memory impairments. Several mechanisms are known that might counteract this decline in cognitive functions. Here, we give an overview of ageing-related changes in neurogenesis in the brain of humans and rodents. We discuss possible causes for reduced neurogenesis with age, its consequences on cognition, and how neurogenesis might be restored in old age.
More Related Videos
08:16Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
Published on: October 20, 2022
07:25Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
Published on: August 20, 2020
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Role of Hippocampus in Memory
Alzheimer Disease ll: Pathophysiology