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Updated: Apr 20, 2026
MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model
Published on: March 13, 2012
A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused
Hsin-Yang Huang1, Hao-Li Liu, Po-Hung Hsu
1Department of Materials Science and Engineering, National Chiao Tung University, No. 1001 Ta-Hsueh Rd., Taiwan, Hsinchu, 300, Republic of China.
Abstract:
A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.
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