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Updated: Apr 20, 2026
Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue
Published on: May 28, 2015
Parvalbumin expression and distribution in the hippocampal formation of Cebus apella
Laila Brito Torres1, Bruno Henrique Silva Araujo, Klena Sarges Marruaz
1Universidade Federal de São Paulo, Unifesp/EPM, Departamento de Neurologia e Neurocirurgia, Laboratório de Neurociências, São Paulo, Brazil; Hospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo, Brazil; Instituto Evandro Chagas (IEC), Centro Nacional de Primatas (CENP), Ananindeua, Brazil.
Abstract:
New World primates play an important role in biomedical research. However, the literature still lacks information on many structural features of the brain in these species, particularly structures of the hippocampal formation that are related to long-term memory storage. This study was designed to provide information, for the first time, about the distribution and number of neurons expressing parvalbumin-immunoreactivity (PV-I) in the subregions of the hippocampal formation in Cebus apella, a New World primate species commonly used in biomedical research. Our results revealed that for several morphometric variables, PV-I cells differ significantly among the subregions CA1, CA2, CA3, and the hilus. Based upon our findings and those of other studies, we hypothesize that the proportional increase from monkeys to humans in PV-I cell density within CA1 is a factor contributing to the evolution of increased memory formation and storage.
