Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

3.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
3.0K
Multiple Allele Traits01:49

Multiple Allele Traits

39.3K
The Concept of Multiple Allelism
39.3K
Spermatogenesis01:41

Spermatogenesis

125.2K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
125.2K
Spermatogenesis01:22

Spermatogenesis

11.5K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
11.5K
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

9.2K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
9.2K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.6K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coping Strategies and Social Support for Transition Readiness Among Youth With Sickle Cell Disease.

JAMA network open·2026
Same author

Community health worker support to adolescents and young adults with sickle cell disease: A multi-method analysis on transition-related support.

Health care transitions·2026
Same author

Recruitment and retention of young adults with sickle cell disease.

Health care transitions·2026
Same author

Characterizing Engagement With a Mobile Health Application Designed for Adolescents and Young Adults With Sickle Cell Disease: Findings From the COMETS Study.

Pediatric blood & cancer·2026
Same author

Improving Healthcare Efficiency and Patient Outcomes Through Proactive Insight to Action: A Sickle Cell Disease Case Example.

Journal of patient experience·2025
Same author

Community health workers supporting emerging adults with sickle cell disease.

Health care transitions·2025

Related Experiment Video

Updated: Apr 20, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.5K

Reproductive issues in sickle cell disease.

Kim Smith-Whitley1

  • 1Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA.

Blood
|December 5, 2014
PubMed
Summary

Reproductive health is increasingly important for sickle cell disease (SCD) patients. This review covers fertility, gonadal function, and long-term therapy impacts on reproduction in SCD.

Area of Science:

  • Hematology
  • Reproductive Medicine
  • Genetics

Background:

  • Improving survival in sickle cell disease (SCD) necessitates greater focus on reproductive health.
  • Reproductive concerns, including fertility and gonadal function, are rising priorities for the SCD community.

Purpose of the Study:

  • To review the multifaceted reproductive issues in sickle cell disease (SCD).
  • To discuss the impact of SCD therapies on fertility and explore fertility preservation options.

Main Methods:

  • Literature review of reproductive health in sickle cell disease (SCD).
  • Analysis of factors affecting male and female fertility in SCD.
  • Examination of the effects of long-term SCD treatments on reproductive outcomes.

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.7K

Related Experiment Videos

Last Updated: Apr 20, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.5K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.7K

Main Results:

  • Male infertility in SCD is linked to hypogonadism, erectile dysfunction, sperm issues, and treatment complications.
  • Female infertility in SCD is less understood but includes menstrual cycle pain and contraception needs.
  • Long-term therapies like iron overload and hydroxyurea impact gonadal function and fertility, with fertility preservation options available post-transplant.

Conclusions:

  • Reproductive health management is crucial for improving quality of life in sickle cell disease (SCD) patients.
  • Further research is needed to fully understand and address female infertility in SCD.
  • Careful consideration of reproductive impacts is essential when managing long-term SCD therapies.