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Updated: Apr 20, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Five hematologic tests and treatments to question
Lisa K Hicks1, Harriet Bering2, Kenneth R Carson3
1University of Toronto, St. Michael's Hospital, Toronto, Ontario, Canada;
The American Society of Hematology (ASH) updated its Choosing Wisely(®) recommendations, advising against certain tests and treatments for conditions like venous thromboembolism and sickle cell disease to improve patient care.
Area of Science:
- Hematology
- Medical Stewardship
- Evidence-Based Medicine
Background:
- Choosing Wisely(®) is a national initiative promoting appropriate medical care.
- The American Society of Hematology (ASH) previously released guidelines in 2013.
- There is a need to refine clinical practices based on the latest evidence.
Purpose of the Study:
- To present five new evidence-based recommendations from ASH for the Choosing Wisely(®) campaign.
- To guide clinicians and patients in questioning specific tests and treatments.
- To reduce unnecessary medical interventions and improve patient outcomes.
Main Methods:
- Utilized the established evidence-based methodology from the 2013 ASH Choosing Wisely(®) list.
- Reviewed current clinical evidence and expert consensus.
- Focused on specific hematologic conditions and common interventions.
Main Results:
- Recommendation 1: Limit anticoagulation to 3 months for first venous thromboembolic events with transient risk factors.
- Recommendation 2: Avoid routine transfusions for chronic anemia or uncomplicated pain crises in sickle cell disease.
- Recommendation 3: Do not perform baseline/surveillance CT scans for asymptomatic early-stage chronic lymphocytic leukemia.
- Recommendation 4: Avoid testing/treating for heparin-induced thrombocytopenia with low pretest probability.
- Recommendation 5: Treat immune thrombocytopenia only if bleeding or platelet count is very low.
Conclusions:
- These ASH Choosing Wisely(®) recommendations aim to optimize patient care by reducing unnecessary interventions.
- Clinicians and patients should engage in shared decision-making regarding these specific tests and treatments.
- Adherence to these guidelines can lead to more appropriate and effective hematologic care.
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