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Updated: Apr 20, 2026

The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors
Published on: February 13, 2026
Endoscopic submucosal dissection for colorectal neoplasms: a review
Taku Sakamoto1, Genki Mori1, Masayoshi Yamada1
1Taku Sakamoto, Genki Mori, Masayoshi Yamada, Yuzuru Kinjo, Eriko So, Seiichiro Abe, Yosuke Otake, Takeshi Nakajima, Takahisa Matsuda, Yutaka Saito, Endoscopy Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Colorectal endoscopic submucosal dissection (ESD) offers improved quality of life for patients with large rectal lesions by enabling en bloc resection. However, technical challenges limit its widespread adoption compared to gastric ESD.
Area of Science:
- Gastroenterology
- Endoscopic Surgery
Background:
- Colorectal endoscopic submucosal dissection (ESD) expands endoscopic treatment options for low-metastatic potential lesions.
- ESD allows en bloc resection, reducing local recurrence rates compared to piecemeal endoscopic mucosal resection.
Purpose of the Study:
- To review the methods, devices, and training for colorectal ESD.
- To highlight the indications, technical challenges, and complications of colorectal ESD.
Main Methods:
- Review of existing literature on colorectal ESD techniques and outcomes.
- Discussion of device types and necessary endoscopist training.
Main Results:
- ESD is beneficial for large rectal lesions, improving patient quality of life.
- Colorectal ESD is technically challenging, with longer procedure times and higher perforation risks than gastric ESD.
Conclusions:
- Understanding ESD indications, techniques, and complications is crucial for its broader application in colorectal neoplasm treatment.
- Further training and standardization are needed to overcome barriers to colorectal ESD adoption.
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