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Wilms' tumour and related syndromes. A unifying theory
1Genetics Division, Institute of Child Health, Athens, Greece.
Annales De Genetique
|January 1, 1989
Abstract:
The major role of somatic crossing-over in the aetiology of Wilms' tumour and other forms of cancer is emphasized. A model is proposed to show that tumour development is due to a cis-trans disruptive effect of somatic crossing-over on the maintenance of differential parental imprinting.