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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Pharmacogenomics: Identification of New Drug Targets01:29

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Genomic data sharing for translational research and diagnostics.

Peter N Robinson1

  • 1Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353 Germany ; Berlin Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353 Germany ; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin, 14195 Germany ; Institute for Bioinformatics, Department of Mathematics and Computer Science, Freie Universität Berlin, Takustrasse 9, Berlin, 14195 Germany.

Genome Medicine
|December 5, 2014
PubMed
Summary
This summary is machine-generated.

Federated queries enable secure, simultaneous searching of distributed genomic data. This approach is crucial for advancing translational genomics and improving patient care through enhanced data sharing.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Data Science

Background:

  • Translational genomics holds significant promise for enhancing patient care.
  • The advancement of genomics is intrinsically linked to evolving data sharing technologies.
  • Secure and powerful data-sharing mechanisms are essential to realize the full potential of genomics.

Purpose of the Study:

  • To demonstrate the efficacy of federated queries for genomic data analysis.
  • To highlight a method for secure and simultaneous searching of distributed genomic datasets.

Main Methods:

  • Implementation of federated query systems.
  • Simultaneous searching of sequence variants across multiple distributed data files.

Main Results:

  • Successful demonstration of federated queries for searching sequence variants.
  • Validation of a secure method for accessing distributed genomic data.

Conclusions:

  • Federated queries represent a powerful tool for advancing translational genomics.
  • Secure data-sharing technologies like federated queries are vital for improving patient outcomes through genomics.