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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
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Opioid induced hyperalgesia in anesthetic settings
Hyeon Jeong Lee1, David C Yeomans2
1Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA. ; Department of Anesthesia, Pusan National University School of Medicine, Busan, Korea.
Korean Journal of Anesthesiology
|December 5, 2014
Summary
Opioid-induced hyperalgesia (OIH) is a concerning side effect of opioid use, paradoxically increasing pain sensitivity. This review examines OIH evidence, mechanisms, and management strategies for clinical implications.
Area of Science:
- Anesthesiology
- Pain Management
- Pharmacology
Background:
- Pain quantification and assessment pose significant challenges in research and treatment.
- Opioids combined with anesthetics are popular for intraoperative hemodynamic stability.
- Concerns regarding opioid side effects, particularly opioid-induced hyperalgesia (OIH), have grown over two decades.
Purpose of the Study:
- To review the evidence, mechanisms, and management of opioid-induced hyperalgesia (OIH).
- To elaborate on the clinical implications of OIH in perioperative care.
Main Methods:
- Literature review focusing on OIH.
- Analysis of evidence, mechanisms, and management strategies.
- Examination of clinical implications.
Main Results:
- Opioid use can paradoxically decrease pain thresholds and increase atypical pain (OIH).
- Understanding OIH mechanisms is crucial for effective management.
- Pharmacologic and modulatory strategies are key to addressing OIH.
Conclusions:
- Opioid-induced hyperalgesia (OIH) is a significant clinical concern.
- Effective management of OIH requires a thorough understanding of its mechanisms.
- Further research into OIH is needed to optimize patient care and pain management.
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