Related Experiment Video
Updated: Apr 20, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Metal-free synthesis of ortho-CHO diaryl ethers by a three-component sequential coupling
Fangliang Liu1, Huameng Yang, Xinquan Hu
1College of Chemical Engineering and Materials Science, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
Abstract:
A practical, metal-free, and highly chemoselective approach was developed for the synthesis of ortho-CHO diaryl ethers by a three-component sequential coupling of arynes, N,N-dimethylformamide (DMF), and diaryliodonium salts. Diverse functional groups including halo, nitryl, and bulky substituents and heteroaromatics are well tolerated. Mechanistically, isotopic tracer experiments reveal that the diaryliodonium salt serves as an electrophile to trap the transient intermediates generated from the [2 + 2] cyclization of an aryne and DMF.
More Related Videos
06:46Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
07:14Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Related Concept Videos
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Cycloaddition Reactions: Overview
Aryldiazonium Salts to Azo Dyes: Diazo Coupling