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Nintedanib: from discovery to the clinic

Gerald J Roth1, Rudolf Binder, Florian Colbatzky

  • 1Department of Medicinal Chemistry; §Department of Drug Metabolism and Pharmacokinetics; ‡Department of Non-Clinical Drug Safety; ∥Department of Translational Medicine and Clinical Pharmacology; ⊥Department of Respiratory Diseases Research; and #Corporate Division Medicine, TA Oncology, Boehringer Ingelheim Pharma GmbH & Co. KG , 88397 Biberach an der Riss, Germany.

Journal of Medicinal Chemistry
|December 5, 2014
PubMed
Summary

Nintedanib, a triple angiokinase inhibitor, effectively treats non-small cell lung cancer (NSCLC), ovarian cancer, and idiopathic pulmonary fibrosis (IPF). This review details its preclinical and clinical development, highlighting significant efficacy in phase III studies.

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