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Updated: Aug 8, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
A comparative study of event-related coupling patterns during an auditory oddball task in schizophrenia
Alejandro Bachiller1, Jesús Poza, Carlos Gómez
1Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Valladolid, Spain.
Objective:
The aim of this research is to explore the coupling patterns of brain dynamics during an auditory oddball task in schizophrenia (SCH).
Approach:
Event-related electroencephalographic (ERP) activity was recorded from 20 SCH patients and 20 healthy controls. The coupling changes between auditory response and pre-stimulus baseline were calculated in conventional EEG frequency bands (theta, alpha, beta-1, beta-2 and gamma), using three coupling measures: coherence, phase-locking value and Euclidean distance.
Main Results:
Our results showed a statistically significant increase from baseline to response in theta coupling and a statistically significant decrease in beta-2 coupling in controls. No statistically significant changes were observed in SCH patients.
Significance:
Our findings support the aberrant salience hypothesis, since SCH patients failed to change their coupling dynamics between stimulus response and baseline when performing an auditory cognitive task. This result may reflect an impaired communication among neural areas, which may be related to abnormal cognitive functions.
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