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Channel Rhodopsins

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Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
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Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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Related Experiment Video

Updated: Apr 19, 2026

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

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Watching single molecules move in response to light.

Pintu K Kundu1, Rafal Klajn

  • 1Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 76100, Israel.

ACS Nano
|December 5, 2014
PubMed
Summary

Scientists are developing artificial molecular machines that mimic nature's solar energy use. New research uses force microscopy to observe how individual photoresponsive molecules change shape when exposed to light.

Area of Science:

  • Molecular engineering and nanotechnology
  • Biomimetic materials science

Background:

  • Nature efficiently harnesses solar energy for biological processes.
  • Man-made molecular photoswitches offer potential to surpass natural systems.
  • Developing light-controlled artificial molecular machines requires understanding photoisomerization-coupled conformational changes.

Discussion:

  • Force microscopy reveals individual photoresponsive molecule behavior.
  • Light-induced isomerization triggers molecular conformational changes.
  • Observed events include contraction, extension, and crawling of molecules.

Key Insights:

  • Detailed insights into individual photoresponsive molecule dynamics.
  • Understanding of light-induced isomerization and conformational coupling.

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  • Identification of specific molecular motion events.
  • Outlook:

    • Potential for designing advanced multifunctional materials.
    • Advancing light-controlled molecular machines and nanotechnology.
    • Overcoming challenges in artificial molecular system development.