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Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays
Published on: April 23, 2012
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[Characteristics of mycotoxin accumulation in lichens]
Prikladnaia Biokhimiia I Mikrobiologiia
|December 6, 2014
Summary
Mycotoxins like alternariol and citrinin were found in most lichen genera studied. This highlights the need for safety monitoring of lichen-derived drugs.
Area of Science:
- Mycology
- Lichenology
- Environmental Science
Context:
- Lichens are widely used in traditional medicine and drug development.
- Mycotoxin contamination in natural products is a growing concern.
- Enzyme immunoassay was employed to characterize mycotoxin accumulation.
Purpose:
- To quantify and identify mycotoxins in 20 genera of lichens.
- To assess the prevalence and levels of specific mycotoxins.
- To discuss the implications for the safety of lichen-based pharmaceuticals.
Summary:
- Mycotoxins including alternariol, sterigmatocystin, mycophenolic acid, citrinin, cyclopiazonic acid, and emodin were frequently detected in 20 lichen genera.
- These mycotoxins were present at average levels exceeding 1000 ng/g in all genera except Peltigera.
- The findings indicate a widespread occurrence of mycotoxins in diverse lichen species.
Impact:
- This study underscores the critical need for rigorous safety monitoring of pharmaceutical products derived from lichens.
- Understanding mycotoxin profiles in lichens is essential for quality control and risk assessment.
- The research contributes to ensuring the safety and efficacy of lichen-derived therapeutics.
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